Quality of Life in Thalassemia Patients After Unrelated Hematopoietic Stem Cell Transplantation

60 Journal of Medicine and The Person, June 2008, vol.6, number 2: 60-64 I NVITED PAPER eccentric of life in thalassemia patients subsequently unrelated haematopoietic hold jail cell transplanting Qualità della vita in pazienti talassemici dopo trapianto non correlato di cellule staminali emopoietiche Caocci Giovanni1, Pisu Salvatore2, La Nasa Giorgio1 1 Centro Trapianti Midollo Osseo, Ospedale R. Binaghi, Cattedra di Ematologia, Università di Cagliari, Cagliari, Italy. 2 Cattedra di Medicina Legale, Università di Cagliari, Cagliari, Italy Abstract thalassaemia major is a chronic, progressive hemoglobin disorder requiring life-long blood transfusion and iron chelation therapy for survival. Extensive ongoing medical c be in this pathology may have a considerable match on the physical, psychosocial well-being and quality of life (QoL) of patients and their families. Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the exclusi vely cure getable for thalassemia. Unfortunately, only a substantial minority of patients have an HLA congenial bestower within the family. More than 70 percent of patients need to look for an unrelated compatible sponsor in voluntary sponsor registries worldwide.

The transplantation-related mortality risk of unrelated HSCT in adult thalassemia patients has been estimated to be about 30%. For this reason, patients without a family donor be faced with the difficult choice between accepting the aristocratical risks of radical treatment or putting aside their hopes of retrieval and continuing regular transfu sion and iron chelation therapy. This comple! x finis-making performance raises several social, psychological and ethical problems. The central ethical build up do of HSCT in a non-malignant disease can be close in in terms of a encounter between cardinal fundamental principles of medical ethics: non-maleficence and kindliness; the question arises as to who will be responsible for the decision and what criteria can be used to strike a comely balance...If you want to posture a full essay, order it on our website: OrderCustomPaper.com

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